Webinars & Videos

Webinars & Videos

Technology Webinars

Dovetail Genomics® Company Overview

Dovetail Genomics is the leader in the field of chromatin conformation capture (HiC). Watch this video to learn more about our novel solutions enabling new science in the fields of epigenetics, developmental biology, drug discovery, cancer research, and evolutionary biology.

Intro to HiChIP MNase Technology

The Dovetail® HiChIP MNase combines the benefits of ChIP-seq wiht the long-range information of Hi-C, enabling genome wide mapping of protein-directed topological features. Identify locally bound-sequences and distal interactions up to megabases away, mediate by your protein of interest (e.g. promoter/enhahcer interactions). Learn more!

Intro to Dovetail® Micro-C Technology

The Dovetail® Micro-C Kit enables capture of chromatin topology at a mono-nucleosome resolution. Watch this webinar and discover how you can get the highest resolution achievable with uniform sequence coverage or save on sequencing costs. Enjoy the next evolution to Hi-C for high-resolution mapping of chromatin topological features.

Intro to Dovetail® Omni-C® Technology

The Omni-C Kit supports multiple whole genome sequencing applications:
-Large structural variant detection
-SNP and InDel genotyping
-Perform genome assembly
-Perform haplotype phasing
-Capture chromatin conformation data

Breaking the Hi-C Resolution Barrier

In this webinar, learn how:
– Using MNase delivers the highest resolution in chromatin conformation
– Increased signal-to-noise ratios translates to reduced sequencing burdens
– Micro-C captures features that other Hi-C approaches have difficultly detecting
– Micro-C an be leveraged in protein-direct approaches to chromatin capture assays

Define Chromatin Architecture at the Nucleosome Level

From the creators of the Dovetail® HiChIP and Micro-C assays respetively, Marco Blanchette (VP R&D) and LIsa Munding (Lead Scientist) share the history behind developing these game changing assay kits for epigenetic research. Hear how the kits work, their benefits, and the ways Marco and Lisa see these new technologies impacting genomics research.

Redefining the
Hi-C Toolbox

During this seminar, you’ll learn how:
– Hi-C addresses a variety of epigenetics questions
– The Dovetail® Omni-C® Kit expands the utility of Hi-C to include WGS applications
– The Dovetail® Micro-C Kit generates high resolution views of genome topology
– The Dovetail® HiChIP MNase Kit maps protein-directed chromatin architecture

Pan Promoter Panels: Targeted Enhancer-Promoter Studies

Enriching our understanding of gene regulation – a targeted view linking promoters with their regulatory elements.

Enhancer-Promoter Interactome

The Role of the Enhancer-Promoter Interactome in Determining Cell Identity

Beyond the Matrix: Analyzing HiChIP Data

What you’ll learn:
– What is loop calling when it comes to HiChIP
– The tool landscape: the trade-off’s and benefits
– How to identify statistically significant interactions
– How to plot HiChIP arcs in R
– Calling 1-D peaks with MACS2 with HiChIP data

Beyond the Matrix: Analyzing Micro-C Data

Integrating HiChIP into your workflow

Learn about:
– MNase-HiChIP and what makes it different from other HiChIP
– Wet lab process (method overview, QC metrics)
– Data processing

Integrating Micro-C Into Your Workflow

You’ll learn:
– What makes Micro-C different from Hi-C
– Wet lab process (method overview, QC metrics)
– Data processing Micro-C

Epigenetics and Human Disease Webinars

Next-Gen Epigenetics to Understand Why We Age

David Sinclar, Ph.D.Harvard Medical School

Elucidating Mechanisms of Cancer Cell Immortality

Dirk Hockemeyer, Ph.D.
UC Berkeley

Dovetail Inspired Science Webinar Series

In this talk, Dr. Hockemeyer will discuss the use of Dovetail® Hi-C technology to assemble Indian and Chinese muntjac genomes to investigate telomere biology and chromosome fusion events in human cancer.

 

Presented live on December 10th, 2020

Integrate the Regulatory Interactome in Your Research

Cory Padilla, Ph.D.
Dovetail Genomics

Structural Variation Detection by Proximity Ligation from FFPE Tumor Tissue

Helio Costa, Ph.D.
Stanford University

Linking Sequence Variation to Chromatin Dynamics through Genome Topology

Cory Padilla, Ph.D.
Dovetail Genomics

Key discussion points:
– The role of genome conformation in gene regulation
– Why integrating conformation data with genotyping data can provide a more complete view of variants
– How to capture variants (SNVs and structural variants) with conformation in a single sequencing library

Genome Assembly Webinars

Directed Evolution of Genome Assemblies - and Why it is Important

Harris Lewin, Ph.D.
UC Davis

Trace the directed evolution of 28 genome assemblies of the Narwhal, an iconic cetacean known at the “unicorn of the sea”. While understanding the evolution and amazing phenotypes of the Narwhal is the ultimate goal, the evolution of genome assemblies from short-read to long read-based assemblies with Dovetail scaffolding has been an interesting scientific journey in itself. Different sequencing approaches will be discussed in the light of genome assembly evolution, and their importance for understanding genome biology.

Assembling a Reference-Quality Genome for Solemya velum (Bivalvia: Protobranchia)

Vanessa L. González, Ph.D.
Smithsonian Institution

We generated a reference-quality genome Solemya velum (Bivalvia: Protobranchia) to allow us to test hypotheses about mollusc genome evolution and the symbiotic interactions in marine molluscs. 10X Genomics, PacBio Long-reads and Hi-C data was leveraged for molluscan genome assembly. Iterations and combinations of each data type have resulted in a 2.4 GB reference genome with a scaffold N50 of 200 MB and a BUSCO completeness score of 93.7%.

Chromosome Length Scaffolds of the lxodes scapularis Genome

Monika Gulia-Nuss, Ph.D.
University of Nevada, Reno

The Genes in the Beans: Tools to Improve Coffee Breeding

Susan Strickler, Ph.D.
Boyce Thompson Institute

Enabling Anolis Lizard Evolutionary Genomics

Anthony Geneva, Ph.D.
Drexel University

Sequencing & Assembling the Mega-Genomes of Mega-Trees

Steven Salzberg, Ph.D.
Johns Hopkins University

The giant sequoia and the coast redwood are two of the largest living organisms. We’ll discuss our successful genome assembly of a 1360-year-old sequoia that produced the largest scaffold of any genome ever attempted and our near-complete work on the genome of a 1390-year-old coast redwood. Both projects used a combination of short reads and long Oxford Nanopore reads for initial assembly, and Hi-C linked reads from Dovetail Genomics for scaffolding.

Disruptive Technologies Improving Disease Resistance in Crop Plants

Richard Michelmore, Ph.D.
UC Davis

High-Quality Genome Assemblies for Non-Model Organisms

Richard Green, Ph.D.
UCSC

Enabling Non-Model Genomics Through de novo Genome Assembly

Ellie Armstrong, Ph.D. Candidate
Stanford University