The Dovetail^® HiChIP MNase combines the benefits of ChIP-seq wiht the long-range information of Hi-C, enabling genome wide mapping of protein-directed topological features. Identify locally bound-sequences and distal interactions up to megabases away, mediate by your protein of interest (e.g. promoter/enhahcer interactions). Learn more!

The Dovetail^® Micro-C Kit enables capture of chromatin topology at a mono-nucleosome resolution. Watch this webinar and discover how you can get the highest resolution achievable with uniform sequence coverage or save on sequencing costs. Enjoy the next evolution to Hi-C for high-resolution mapping of chromatin topological features.

The Omni-C Kit supports multiple whole genome sequencing applications:
-Large structural variant detection
-SNP and InDel genotyping
-Perform genome assembly
-Perform haplotype phasing
-Capture chromatin conformation data

In this webinar, learn how:
– Using MNase delivers the highest resolution in chromatin conformation
– Increased signal-to-noise ratios translates to reduced sequencing burdens
– Micro-C captures features that other Hi-C approaches have difficultly detecting
– Micro-C an be leveraged in protein-direct approaches to chromatin capture assays

From the creators of the Dovetail^® HiChIP and Micro-C assays respetively, Marco Blanchette (VP R&D) and LIsa Munding (Lead Scientist) share the history behind developing these game changing assay kits for epigenetic research. Hear how the kits work, their benefits, and the ways Marco and Lisa see these new technologies impacting genomics research.

During this seminar, you’ll learn how:
– Hi-C addresses a variety of epigenetics questions
– The Dovetail^® Omni-C^® Kit expands the utility of Hi-C to include WGS applications
– The Dovetail^® Micro-C Kit generates high resolution views of genome topology
– The Dovetail^® HiChIP MNase Kit maps protein-directed chromatin architecture

Enriching our understanding of gene regulation – a targeted view linking promoters with their regulatory elements.

The Role of the Enhancer-Promoter Interactome in Determining Cell Identity

What you’ll learn:
– What is loop calling when it comes to HiChIP
– The tool landscape: the trade-off’s and benefits
– How to identify statistically significant interactions
– How to plot HiChIP arcs in R
– Calling 1-D peaks with MACS2 with HiChIP data

Learn about:
– MNase-HiChIP and what makes it different from other HiChIP
– Wet lab process (method overview, QC metrics)
– Data processing

You’ll learn:
– What makes Micro-C different from Hi-C
– Wet lab process (method overview, QC metrics)
– Data processing Micro-C

Dovetail Inspired Science Webinar Series

In this talk, Dr. Hockemeyer will discuss the use of Dovetail^® Hi-C technology to assemble Indian and Chinese muntjac genomes to investigate telomere biology and chromosome fusion events in human cancer.

 

Presented live on December 10th, 2020

Key discussion points:
– The role of genome conformation in gene regulation
– Why integrating conformation data with genotyping data can provide a more complete view of variants
– How to capture variants (SNVs and structural variants) with conformation in a single sequencing library

The giant sequoia and the coast redwood are two of the largest living organisms. We’ll discuss our successful genome assembly of a 1360-year-old sequoia that produced the largest scaffold of any genome ever attempted and our near-complete work on the genome of a 1390-year-old coast redwood. Both projects used a combination of short reads and long Oxford Nanopore reads for initial assembly, and Hi-C linked reads from Dovetail Genomics for scaffolding.

The event will highlight how nucleosome-based approaches have advanced our understanding of chromatin conformation and its role in gene regulation. Across diverse application areas, spanning academic research through disease and drug development, these researchers are leveraging nucleosome-centric conformation to further their understanding and to make breakthrough discoveries.

This event will highlight how nucleosome-based approaches have advanced our understanding of chromatin conformation and its role in gene regulation. Across diverse application areas, spanning academic research through disease and drug development, these researchers are leveraging nucleosome-centric conformation to further their understanding and to make breakthrough discoveries.