Dovetail® TopoLink™ Kit

Catalog # 25018

Dovetail® TopoLink™ Kit

Catalog # 25018

Dovetail TopoLink Kit

Access the 3D genome at unparalled speed. Dovetail® TopoLink™ offers the fastest proximity ligation method available today – without sacrificing data quality. The only complete solution that integrates proximity ligation with NGS library prep, TopoLink enables the user to go from sample to sequencing library in less than 6 hours. Whether you are mapping A/B compartments, identifying TAD boundaries, or capturing chromatin loops, TopoLink offers the fastest end-to-end workflow. All while delivering highly uniform sequence coverage, increased discovery rate, and superior accuracy.

Sample to Sequencing Library – In Less Than 6 Hours!

TopoLink Assays are the only complete solution that integrates proximity ligation with NGS library prep. Whether you are mapping A/B compartments, identifying TAD boundaries, or capturing chromatin loops, the TopoLink Assay offers the fastest end-to-end workflow.

  • Genomic interaction data in less than half the time of alternative approaches
  • Highly uniform sequence coverage maximizing discovery potential
  • Chromatin topology down to nucleosome resolution

Increase the Discovery Rate of Genomic Interactions Features

TopoLink™ data delivers unbiased and uniform genomic coverage, resulting in richer contact matrices and increased chromatin loop detection compared to Hi-C data.

  • Genomic Coverage: Per-base coverage histograms displaying the number of bases at a given coverage rate.
  • Contact Matrices: Improved coverage leads to more complete contact matrices.
  • Loop Calls: Loop calls at 5 kb and 10 kb resolutions, resulting loops were de-replicated and merged.
Uniform Genomic Coverage with TopoLink
Richer Contact Matrices with TopoLink
Increased chromatin loop detection with TopoLink

Rapid Genomic Interaction Integration with Other NGS Markers

Leverage existing tools to quickly and easily integrate TopoLink data with other genomic and epigenomic data. Visualize RNA-seq, ChIP-seq, and ATAC-seq along side chromatin loops and interaction matrices in the WashU Epigenome Browser. Easily contextualize detected TADs, loops and enhancer-promoter dynamics with other genomic features..

TopoLink Integration with WashU Epigenome Browser

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