TopoLink Assays are the only complete solution that integrates proximity ligation with NGS library prep. Whether you are mapping A/B compartments, identifying TAD boundaries, or capturing chromatin loops, the TopoLink Assay offers the fastest end-to-end workflow.

• Genomic interaction data in less than half the time of alternative approaches
• Highly uniform sequence coverage maximizing discovery potential
• Chromatin topology down to nucleosome resolution

TopoLink™ data delivers unbiased and uniform genomic coverage, resulting in richer contact matrices and increased chromatin loop detection compared to Hi-C data.

• Genomic Coverage: Per-base coverage histograms displaying the number of bases at a given coverage rate.
• Contact Matrices: Improved coverage leads to more complete contact matrices.
• Loop Calls: Loop calls at 5 kb and 10 kb resolutions, resulting loops were de-replicated and merged.

Leverage existing tools to quickly and easily integrate TopoLink data with other genomic and epigenomic data. Visualize RNA-seq, ChIP-seq, and ATAC-seq along side chromatin loops and interaction matrices in the WashU Epigenome Browser. Easily contextualize detected TADs, loops and enhancer-promoter dynamics with other genomic features..

Can’t wait to get started