Dovetail® TopoLink™ Kit
Catalog # 25018
Dovetail® TopoLink™ Kit
Catalog # 25018

Sample to Sequencing Library – In Less Than 6 Hours!
TopoLink Assays are the only complete solution that integrates proximity ligation with NGS library prep. Whether you are mapping A/B compartments, identifying TAD boundaries, or capturing chromatin loops, the TopoLink Assay offers the fastest end-to-end workflow.
- Genomic interaction data in less than half the time of alternative approaches
- Highly uniform sequence coverage maximizing discovery potential
- Chromatin topology down to nucleosome resolution

Increase the Discovery Rate of Genomic Interactions Features
TopoLink™ data delivers unbiased and uniform genomic coverage, resulting in richer contact matrices and increased chromatin loop detection compared to Hi-C data.
- Genomic Coverage: Per-base coverage histograms displaying the number of bases at a given coverage rate.
- Contact Matrices: Improved coverage leads to more complete contact matrices.
- Loop Calls: Loop calls at 5 kb and 10 kb resolutions, resulting loops were de-replicated and merged.



Rapid Genomic Interaction Integration with Other NGS Markers
Leverage existing tools to quickly and easily integrate TopoLink data with other genomic and epigenomic data. Visualize RNA-seq, ChIP-seq, and ATAC-seq along side chromatin loops and interaction matrices in the WashU Epigenome Browser. Easily contextualize detected TADs, loops and enhancer-promoter dynamics with other genomic features..

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