Breaking the Hi-C Resolution Barrier​: Micro-C enables chromatin conformation capture at the nucleosome level​

Key discussion points:

  • How the use of MNase in Micro-C assays enables the highest resolution in chromatin conformation
  • Why Micro-C has increased signal-to-noise ratio and what this means for reducing the sequencing burden of conformation studies
  • The types of features Micro-C captures that other Hi-C approaches have difficulty detecting, including enhancer-promoter and promoter-promoter interactions
  • How Micro-C can be leveraged in protein-direct approaches to chromatin conformation capture assays