Proximity ligation offers an unprecedented view into genome conformation and architecture.

Genome conformation mapping tech­nologies have facilitated an unprecedented view of the three-dimensional organization of the genome.

Methods like Dovetail™ Hi-C have enabled the study of topologically associated domains and chromatin loop­ing that are important in gene regulation and epi­genetics.

Approximately 20% of the mappable human genome is blind to Hi-C due to low restriction enzyme site density and analyses of Hi-C data are dependent on capturing these sites.

Dovetail Genomics latest Hi-C technology, Omni-C™, increases the genomic coverage of a proximity-ligation assay, therefore expanding the efficiency of each sequencing run by covering more of the genome and reducing biases imposed by restriction enzyme site density.

Learn More about Omni-C™

Featured Resources

Omni-C™ Tech Note

Omni-C™: A sequence-independent endonuclease-based Dovetail™ proximity-ligation protocol

OC_techNote

The Omni-C™ Award Program

Dovetail Genomics is excited to put the Omni-C™ kit into the hands of the community through the Omni-C™ Award Program.

Through September 30, 2019, we are welcoming submissions for projects that will benefit from the superior uniformity of coverage Omni-C™ delivers.

Want More? Visit the Resources Archive

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Contact us to discover more about this breakthrough technology and how it can help complete your view of the genome.

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