Thanks for attending GAP 2022! Apply for a Funding Assistance Award to help lower costs on your next de novo genome assembly project!

Basic awards of up to $8,000. De novo genome assemblies starting from $15,500 (with award applied). See below for more details

At Dovetail Genomics, we strive to provide the best quality genome assemblies at reasonable prices. We are constantly looking for ways to lower costs, while preserving our industry-leading level of quality. In addition to our standard pseudo haploid assembly deliverable, you now have the option to upgrade to haplotype-resolved (true diploid) assembly with chromosome-scale phasing.

The Dovetail Funding Assistance Award Program (FAA) provides funding assistance to qualified applicants.

Awards Available:

  • PacBio HiFi + + Omni-C scaffolding and pseudo haploid assembly: $5,500 award
  • OR
  • PacBio HiFi + Omni-C scaffolding and haplotype-resolved assembly: $8,000 award
  • OR
  • Omni-C scaffolding of an existing assembly: $3,000 award

Examples of Award calculations and out-of-pocket expenses, assuming a full de novo assembly with no genome annotation (Award option (1) from above):

Complete Pseudohaploid Assembly

Genome Size List Price * Less Award Final Price With Annotation
600 Mb $21,00 -$5,500 $15,500 $20,000
1.3 Gb $24,750 -$5,500 $19,250 $23,750
3.0 Gb $36,000 -$5,500 $30,500 $35,000

Haplotype-resolved assembly

Genome Size List Price * Less Award Final Price With Annotation
600 Mb $26,000 -$8,000 $18,000 $22,500
1.3 Gb $29,750 -$8,000 $21,750 $26,250
3.0 Gb $41,000 -$8,000 $33,000 $37,500

Omni-C scaffolding of existing assembly

Genome Size List Price * Less Award Final Price With Annotation
600 Mb $13,050 -$3,800 $9,200 $13,750
1.3 Gb $13,050 -$3,800 $9,200 $13,750
3.0 Gb $13,050 -$3,800 $9,200 $13,750

*Prices outlined here are in USD and are only reflective of pricing in countries and regions where Dovetail® sells directly. Pricing may vary for applicants located in regions/countries in which Dovetail works through distributors. Please reach out to info@dovetail-genomics.com if you have questions regarding pricing in your country/region.

How to apply:

Please complete and submit the below application to be considered for the FAA. Applications will be reviewed and accepted on a rolling basis. Submission deadline for applications is 11:59 PM ET on Wednesday, March 9, 2022

Don’t settle for half a genome when you can get more!

Genome assemblies are usually haploid. We are now including chromosome-scale phased SNP calling at no extra cost for our FAA awardees. The VCF file will provide you with chromosome-scale phased SNP calls that can contribute to a better understanding of:

  • Hybridization
  • Distribution of heterozygosity
  • Cis versus trans mutations, such as compound heterozygosity
  • Inbreeding
  • Identification of recessive alleles
  • Allele-specific methylation
  • and more!

Chromosome-scaled phased SNP calling requires 2 things:

1. Highly accurate SNP calls

PacBio HiFi sequencing is the most accurate long read sequencing technology available today.  PacBio HiFi sequencing offers quality scores as high as Q45 (3 errors per 100,000 base pairs, Vollger et. al. 2019).  Highly accurate SNP calling is essential for chromosome-scale phased SNP calling.

Image re-created by Dovetail Genomics using data from:
Ann Hum Genet,. 2020 Mar; 84(2): 125–140.
Published online 2019 Nov 11. doi: 10.1111/ahg.12364

1. Highly accurate SNP calls

PacBio HiFi sequencing is the most accurate long read sequencing technology available today.  PacBio HiFi sequencing offers quality scores as high as Q45 (3 errors per 100,000 base pairs, Vollger et. al. 2019).  Highly accurate SNP calling is essential for chromosome-scale phased SNP calling.

Image re-created by Dovetail Genomics using data from:
Ann Hum Genet,. 2020 Mar; 84(2): 125–140.
Published online 2019 Nov 11. doi: 10.1111/ahg.12364

2. Even and unbiased sequencing coverage compared to traditional Hi-C approaches

Omni-C is the newest Dovetail Hi-C proximity ligation service. Unlike traditional single or multi-restriction enzyme Hi-C methods, Omni-C technology uses a sequence-independent endonuclease to digest chromatin. This enables very even, near shotgun-like sequence coverage of the genome, with no restriction site biases.

To further leverage the power of chromosome-scale phased SNP calling, Omni-C technology can be used for population-scale resequencing. The even and unbiased whole-genome coverage of Omni-C data provides shotgun-like SNP coverage but with the added benefit of chromosome-scale phased SNP calling. The Dovetail Genomics® Omni-C® Kit provides an economical way to resequence multiple samples for popgen analysis. See App Note below.

Read the Omni-C All-In-One Application Note