Proximity ligation offers an unprecedented view into 3-D epigenetics and genomic architecture.
Genome conformation mapping technologies have facilitated an unprecedented view of the three-dimensional organization of the genome.
Methods like Dovetail™ Hi-C have enabled the study of topologically associated domains and chromatin looping that are important in gene regulation and epigenetics.
While Hi-C has enabled researchers in these areas, there are still notable drawbacks to this method due to the use of restriction enzymes to digest chromatin.
Approximately 20% of the mappable human genome is blind to Hi-C due to low restriction enzyme site density, but analyses of Hi-C data are dependent on capturing these sites.
Dovetail Genomics latest Hi-C technology, Omni-C™, increases the genomic coverage of a proximity-ligation assay, thereby expanding the efficiency of each sequencing run through increased coverage and reducing biases imposed by restriction enzyme site density.