Proximity ligation offers an unprecedented view into 3-D epigenetics and genomic architecture.
Genome conformation mapping technologies have facilitated an unprecedented view of the three-dimensional organization of the genome.
Methods like Dovetail™ Hi-C have enabled the study of topologically associated domains and chromatin looping that are important in gene regulation and epigenetics.
While Hi-C has enabled researchers in these areas, there are still notable drawbacks to this method due to the use of restriction enzymes to digest chromatin.
Dovetail Genomics latest Hi-C technology, Omni-C™, increases the genomic coverage of a proximity-ligation assay, therefore expanding the efficiency of each sequencing run by covering more of the genome and reducing biases imposed by restriction enzyme site density.
Featured Resources
Omni-C™ Tech Note
Omni-C™: A sequence-independent endonuclease-based Dovetail™ proximity-ligation protocol
Application Note
Application Note
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