Proximity ligation offers an unprecedented view into 3D epigenetics and genomic architecture.
Genome conformation mapping technologies have facilitated an unprecedented view of the three-dimensional organization of the genome.
Methods like Hi-C have enabled the study of topologically associated domains and chromatin looping that are important in gene regulation and epigenetics.
While Hi-C has enabled researchers in these areas, there are still notable drawbacks to this method due to the use of restriction enzymes to digest chromatin.